Homo RNA Project

Design synthetic functional RNA molecules given target structure

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The HomoRNA Approach


HOMO-RNA consists of 3 steps:

HomoRNA Format

Utilization of the Special Display Method for the Secondary Structure of RNA

Hierarchical Decomposition

all the RNAs were hierarchically decomposed into smaller substructures, And develop the required database

Solving the Problem

Use the HomoRNA format, and the Presented Database to solving RNA Design Problem Based On Homology Modelling

Try HomoRNA test the server using this sample structure

Some Advantages


The main focus of our method was on using the rules of nature
for solving the problem

Homo Rna Format

A new structural format is proposed for representing RNA 2D structure

Develop a novel algorithm

whose performance is based on the homology modeling approach idea

develop a new database

With the hierarchical decomposition of All RNAs into smaller substructures.

obtain high scores

HomoRNA could obtain higher scores than previous standard procedures

HomoRNA Format


HomoRNA format for each secondary structural element presented here:

HomoRNA Database


Current holdings of HomoRna database:

Primary data

1059

Substructures

25115

Discontinuous parts

9634

Bulge

7177

Stem

31292

Hairpin

11648

Internal-Loop

14632

External Elements

1831

Our Team


IRAN, Tehran, Jala-Ale-Ahmad Street,Tarbiat Modares University, School of Biological Science, Bioinformatics Lab.

Esmaeil Roohparvar

Researcher

Dr. shahriar Arab

Supervisor

Dr. Javad Zahiri

Advisor